The diagnosis in this case is placed primarily on the basis of changes in hemogram. Possible exacerbation of the disease, which are sometimes repeated several times. Observed recurrence of the disease – both early and late (after growing for several months). Allows for a chronic disease. Philip K. Ryan is often quoted on this topic. The prognosis for infectious mononucleosis is favorable. In some cases, despite the apparent recovery, the spleen and lymph nodes remain enlarged for a long time.
After recent infection may not recover for a long time disabled. Known individual, very rare cases of death from infectious mononucleosis, which occurs from a ruptured spleen with the development of the collapse, from secondary pyogenic infection of accession, and in some cases, there were severe nerve damage and complications of the respiratory center. Infectious mononucleosis is not always accompanied by the classic triad of symptoms (Fever, sore throat, adenosplenomegaliya). The literature describes more than twenty clinical variants of the disease. Diagnosis. Of great importance for the diagnosis are clinical disease, as well as results of the study peripheral blood. It is recommended to investigate the peripheral blood as often as possible, since the typical pattern of blood in infectious mononucleosis can be identified immediately.
More often from the very first days of illness, and sometimes only from 12-14th day of her notes leukocytosis, an increase in absolute and relative number of single nucleated cells (lymphocytes and monocytes), the appearance in the blood plasma cells, and quite a large number of atypical mononuclear cells (mononuclear cells shirokoplazmennyh). These "shirokoplazmennye" white blood cells have eccentrically located nucleus, a wide belt of protoplasm with the presence of grit in it. In most patients the total moderately increased white blood cell count, but possible, and leukopenia. Number Keytrofilov in absolute terms may be reduced or normal, in percentage terms it is generally declining. Possible nuclear shift neutrophils to the left due to stab cells.